IV EGCg – Green Tea Extract

Green tea, made from Camellia sinensis leaves, has a long history as a folk remedy for its purported medicinal properties. Its best-known component is epigallocatenin gallate (EGCg). Many people drink green tea, while others take green tea supplements, in order to hopefully obtain health benefits.
Cell line (in vitro) studies have shown that EGCg has antioxidant, anti-inflammatory, and anti-cancer effects. It has also been shown to provide protection against radiation. Unfortunately, these benefits have not been proven in humans consuming green tea. This is because the amount of green tea which must be consumed in order to obtain benefit is not feasible.

Green Tea as an Anti-Cancer Agent

While some studies have shown a benefit from green tea extract on cardiovascular health, we are yet to see any studies documenting its effect against cancer. Regardless of whether or not there is an anti-cancer benefit from green tea supplements, we know that we must overcome the fact that oral ingestion of any substance is inefficient. For this reason, intravenous EGCg makes sense, as the absorption will be at or near 100%.

Research by Claudia Hanau, Ph.D., has shown that intravenous EGCg coupled with a robust oral green tea extract protocol targets a key marker unique to cancer cells. A protein known a ENOX2 has been identified as only being present on, and released by, cancer cells and not healthy cells. ENOX2 was the marker measured by a lab test known as the ONCOblot test to detect the presence of cancer. Subsequent research revealed that ENOX2 is not only unique as a cancer marker, but also required for cancer growth and spread. Thus, intravenous EGCg represents a potentially effective anti-cancer agent as a result of its ability to reduce ENOX2 levels to undetectable.